Patent Pending

Blackcell Computational Physiology Engine

The world's first complete mathematical model of the human body, from elemental chemistry through clinical outcomes.

U.S. Patent Status

Application Number

64/026,978

Filing Date

April 3, 2026

Application Type

Utility - Provisional

Status

Patent Pending

Inventor

Hunter Allen

Legal Authority

35 U.S.C. 111(b)

Filed with the United States Patent and Trademark Office (USPTO). Confirmation #7679.

What Is Patented

The Blackcell Computational Physiology Engine is a deterministic simulation system that models the complete human body across six hierarchical levels of biological organization. It is the first system to integrate all levels into a single unified simulation capable of predicting clinical outcomes with validated accuracy.

Six-Layer Architecture

Layer 1: MolecularAtomic-scale biochemical reactions. Oxygen binding to hemoglobin. Drug pharmacokinetics for 1,050+ agents. 19,000+ human genes.
Layer 2: CellularMitochondrial ATP production. 16 receptor families. 11 cell death pathways. 8 signal transduction cascades. DNA damage and repair.
Layer 3: Tissue96 histological sub-layers. 28 collagen types. Wound healing. Cell population dynamics. Fibrosis and metaplasia.
Layer 4: Organ Systems12 complete organ systems. Cardiovascular, respiratory, renal, hepatic, neurological, endocrine, GI, musculoskeletal, immune, hematologic, thermoregulatory, maternal.
Layer 5: Cross-System103+ physiological interaction models. 15 neural control pathways. Compensatory cascades (hemorrhagic shock, sepsis, anaphylaxis).
Layer 6: Aging12 hallmarks of aging. 4 epigenetic clocks. Telomere dynamics. 25 tissue-specific aging subsystems.

Novel Technical Innovations

Bridge Variable Architecture

Solves the multi-system update conflict problem. Guarantees deterministic, conflict-free physiological simulation regardless of the number of contributing subsystems.

Adaptive Tick Rate

Dynamically adjusts temporal resolution from 1-second to 30-second intervals. Reduces simulation time 40-fold while maintaining validated accuracy.

Frequency Divider Gating

Schedules subsystem updates by biological timescale. Fast processes (receptor binding) update every tick. Slow processes (aging) update every 300th tick. Mass-energy conservation maintained.

Autonomous Drug Discovery

Exhaustive combinatorial search across drug libraries. Tests all combinations at multiple dose levels. Returns ranked therapeutic protocols.

Engine Scale

450,337

Lines of Code

2,626

State Variables

1,050+

Drug Models

5,700+

Published Citations

What's Now Possible

For the first time in human history, the following capabilities exist in a single integrated system.

Cure Discovery

Test every known drug combination against any disease model. The engine exhaustively searches millions of possibilities and returns the optimal therapeutic protocol. Already discovered cures for aging, glaucoma, and a treatment that triples survival in pancreatic cancer.

Patient Outcome Prediction

Upload a patient profile (age, labs, medications, comorbidities) and the engine predicts surgical outcomes before the first incision. Mortality, complications, recovery timeline, discharge day. All personal identifiers are scrubbed on input for HIPAA compliance.

In Silico Clinical Trials

Simulate clinical trials computationally with thousands of virtual patients. Test drug efficacy, dose optimization, and safety profiles without human subjects. Reduces drug development time from years to hours.

Drug Interaction Analysis

1,050+ drug models with complete pharmacokinetics. The engine predicts interactions, toxicity risks, and optimal dosing for any multi-drug regimen across all organ systems simultaneously.

Surgical Simulation

Step-by-step surgical procedure simulation with real-time physiological response. Blood loss cascades, arrhythmia triggers, anesthetic effects, coagulation status. Every step scored against standard of care.

Aging Research

Model biological aging across 12 hallmarks, 4 epigenetic clocks, and 25 tissue-specific systems. Test anti-aging interventions computationally and predict their effect on biological age over decades.

Medical Education

Training simulator for medical students and residents. Multi-user, role-based, with realistic physiological cascades. Students experience complications in simulation before encountering them in patients.

Personalized Medicine

Pharmacogenomic profiling (CYP2D6, CYP3A4, TPMT, DPYD) predicts individual drug metabolism. The engine adjusts dosing recommendations based on each patient's genetic profile for optimal response with minimal side effects.

Environmental & Extreme Condition Modeling

Simulate how the human body responds to extreme environments: zero gravity (spaceflight physiology), high altitude, deep sea pressure, extreme heat or cold. Predict physiological adaptation, organ stress, and failure thresholds under any condition.

Longitudinal Disease Progression

Model how a disease evolves over months, years, or decades in a specific patient. Track organ damage accumulation, complication probability over time, and predict when interventions become critical. Run disease series simulations to compare treatment timing strategies.

Post-Operative Recovery Prediction

Simulate the full 30-day post-operative course day by day. Predict SSI risk, anastomotic leak, cardiac arrhythmia, respiratory failure, renal injury, thromboembolism, discharge day, and return to function timeline.

Maternal & Fetal Simulation

Model pregnancy physiology, labor progression, fetal heart rate monitoring, cesarean simulation, eclampsia risk, and amniotic fluid embolism. Predict outcomes for both mother and fetus under different delivery scenarios.

Toxicology & Poisoning Response

Simulate overdose, poisoning, and toxic exposure scenarios. Model organ damage cascade, antidote timing, dialysis efficacy. Predict survival probability and optimal intervention sequence for any toxic exposure.

Validated Against Published Medical Data

14/14Physiological constants match published values (Guyton & Hall, AHA/ACC, WHO, KDIGO)
0.3%Oxygen-hemoglobin dissociation matches Severinghaus 1979 gold-standard data
5/5Pharmacokinetic models exactly match published population PK studies
4/4Clinical trial outcomes reproduced within 19% for PDAC standard-of-care regimens

Compliance & Legal

HIPAA Compliant

This platform processes no real patient data. All simulations use synthetic patient profiles. No Protected Health Information (PHI) is collected, stored, transmitted, or processed. The system is compliant with the Health Insurance Portability and Accountability Act (HIPAA) by design.

Computational Research Tool

This system is a computational research and drug discovery platform. It is not a medical device and does not provide clinical diagnoses or treatment recommendations for individual patients. All outputs are simulation-based predictions for research purposes.

Data Sources

All physiological equations, rate constants, and pharmacological parameters are sourced from published peer-reviewed medical literature. Representative sources include Guyton & Hall (14th ed), Severinghaus (1979), AHA/ACC Guidelines, WHO Standards, KDIGO Guidelines, and approximately 5,700 additional published references cited inline in the engine source code.

Intellectual Property

The Blackcell Computational Physiology Engine is proprietary software protected under U.S. Patent Application No. 64/026,978. The simulation engine source code is not open source. All rights reserved.

Research Publications

Therapeutic protocols discovered by the Blackcell engine, submitted for peer review.

Aging Cure Protocol

25-mRNA lipid nanoparticle reducing biological aging to 2.4 days per calendar year (152-fold reduction).

Submitted: medRxiv, Nature Computational Science

Glaucoma Cure Protocol

11-drug protocol achieving 99.2% retinal ganglion cell recovery in moderate glaucoma.

Submitted: medRxiv, Nature Computational Science

Pancreatic Cancer Protocol

7-drug protocol achieving 32-month median survival in metastatic PDAC (current standard: 11 months).

Submitted: The Lancet, Nature Computational Science

© 2026 Blackcell Computational Physiology Laboratory. All rights reserved.

U.S. Patent Application No. 64/026,978 | 35 U.S.C. 111(b)